Quercetin Dose Calculator (Allergies / Senolytic / CV)






Quercetin Dose Calculator (Allergies / Senolytic / CV) | UsefulVitamins



Calculate quercetin dose by goal. Flavonoid found in onions, apples, capers. Three main use cases: allergies (mast cell stabilizer), senolytic protocols (with fisetin or dasatinib), cardiovascular / anti-inflammatory. Absorption is poor — form matters. Math, not medical advice.

Your situation





500
mg quercetin / dose, twice daily

Use cases and evidence

  • Allergies: mast cell stabilizer. Mechanism plausible; clinical evidence modest. Pair with vitamin C + bromelain.
  • Cardiovascular: modest BP reduction (3-4 mmHg systolic in hypertensive subjects). Anti-inflammatory effects on endothelium.
  • Senolytic protocol: Mayo Clinic Kirkland protocol pairs quercetin 1000 mg + dasatinib 100 mg for 2 consecutive days/month. Currently in human trials. Quercetin + fisetin is the “natural” version some use.
  • Immune / antiviral: in vitro effects against multiple viruses. Clinical efficacy thin. COVID-era hype unsupported by RCTs.
  • Exercise: small endurance benefit (about 3% VO2max increase in some studies). Probably not noticeable in well-trained athletes.

Senolytic stack (advanced — discuss with clinician)

  • “Hit and run” protocol: senolytics target senescent cells; long-term daily dosing not required (and potentially counterproductive).
  • Kirkland Mayo Clinic protocol: dasatinib 100 mg + quercetin 1000 mg for 2 consecutive days/month. RX dasatinib required — clinical only.
  • “Natural” alternative: fisetin 1000 mg/day for 2 days, monthly. Or quercetin 1000 mg + fisetin 500 mg same protocol.
  • This is experimental. Human evidence is preliminary (small trials in diabetic kidney disease, idiopathic pulmonary fibrosis). Self-experimentation territory.

Interactions and cautions

  • Warfarin / DOACs: quercetin inhibits CYP3A4 + may affect bleeding risk. Monitor INR / consult prescriber.
  • BP medications: additive BP lowering. Monitor BP.
  • Thyroid hormone: quercetin may interfere with thyroid hormone synthesis (animal data). Caution in hypothyroidism.
  • Ciclosporin / tacrolimus: quercetin affects CYP3A4 metabolism of these drugs — concentration changes possible. Coordinate with transplant team.
  • Chemotherapy: some chemo agents are CYP3A4 substrates. Quercetin can alter levels. Discuss with oncologist.

For educational purposes only. Quercetin interacts with warfarin, ciclosporin, and other CYP3A4 substrates. Senolytic protocols are experimental. Consult clinician before adding to any chronic medication regimen. Reliance on this tool is at your own risk.



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