Drug–Supplement Interactions

Valerian and Ativan both enhance GABA, so taking them together can stack sedation. The interaction, the timing, and who should be most careful.

L-theanine is generally considered safe with Xanax and may take the edge off anxiety, but additive calm and the lack of trials mean a few sensible cautions apply.

Kava plus a benzodiazepine can cause excessive sedation and adds two sources of liver and CNS risk. Why this combo warrants real caution – one documented case.

Combining melatonin with Ambien adds two sleep mechanisms – and two sets of sedation risks. Whether it helps, plus the next-day and complex-sleep cautions.

Melatonin and Xanax (alprazolam) are often combined, but both are sedating and the additive drowsiness is real. The interaction, the timing, and the cautions.