Berberine RCT doses ranged from 500 mg to 1,500 mg/day, with the most-cited 500 mg three times a day with meals (Yin 2008 trial vs metformin). Calculator for goal-specific doses with drug interaction warnings. Past-tense trial data, not a prescription. Important: berberine is a strong CYP3A4 inhibitor and P-glycoprotein modulator. It interacts with statins, immunosuppressants, […]

Pick the right B12 form (methylcobalamin, cyanocobalamin, hydroxocobalamin, adenosylcobalamin) for your goal — vegan, MTHFR, B12 deficiency, energy, pregnancy. Most people don’t need the expensive forms. Math, not medical advice. The $200 vitamin store secret: for ~90% of people, $5/year cyanocobalamin works exactly as well as $50/year methylcobalamin. Both convert to active forms in the

Calculate individual B vitamin targets by goal — covers methylcobalamin/methylfolate for MTHFR, niacin form for cholesterol, B6 toxicity ceiling, and the energy/cognitive stack rationale. Math, not medical advice. The “high-potency B-complex” trap: many products contain 1000-5000% RDA of each B vitamin. For most adults this is wasted (water-soluble = excreted in urine) and can be

Calculate an evidence-based athlete recovery stack: creatine + tart cherry + curcumin + omega-3 + HMB by training intensity and goal. Targets inflammation, muscle catabolism, soreness, sleep quality. Warns about the anti-inflammatory paradox during hypertrophy training. Math, not medical advice. The anti-inflammatory paradox: high-dose antioxidants (curcumin, vitamin C, vitamin E) post-workout may BLUNT training adaptations

Convert between KSM-66, Sensoril, and generic ashwagandha extracts by withanolide content. “1,500 mg ashwagandha” on a label tells you almost nothing — the standardized extract amount (with withanolide %) is what matters. Math, not medical advice. The branded extract premium is real: KSM-66 (Ixoreal, full-spectrum root, 5% withanolides) and Sensoril (Natreon, root + leaf, 10%

Calculate apigenin dose by goal — sleep (Huberman 50 mg protocol), longevity / CD38 inhibition, anxiety. Most “chamomile tea sleep” effect is from apigenin’s GABA-A binding. Math, not medical advice. Honest framing: apigenin became popular via Andrew Huberman’s sleep stack (50 mg apigenin + 145 mg magnesium L-threonate + 100-400 mg theanine). Human RCT evidence

Calculate vitamin C dose by goal — RDA, immune support, iron co-factor, or bowel-tolerance protocol. Most absorption saturates around 200 mg per dose, so 1g+ single doses waste most of what you take. Split dosing matters. Math, not medical advice. The saturation truth: intestinal vitamin C absorption is dose-dependent and saturates. ~70-80% of a 200

Compare probiotic supplements by CFU count, strain diversity, and use-case match. A 50-billion-CFU product is not automatically better than a 10-billion one — strain identity matters more than dose. Math + product knowledge, not medical advice. Two things probiotic marketing hides: (1) CFU is measured at time of manufacture, not what reaches your gut —

Generate a custom probiotic schedule for your antibiotic course. Most people take probiotic the wrong way — bacteria-based probiotics taken with antibiotics get killed instantly. S. boulardii (yeast) survives. Calculator shows your optimal day-by-day timing. Math, not medical advice. The 2-hour rule: Lactobacillus and Bifidobacterium probiotics need 2-3 hour separation from antibiotic doses. Saccharomyces boulardii

A “1,000 mg fish oil” softgel typically contains 300 mg of actual EPA+DHA — the other 700 mg is non-omega-3 oil. Calculator decodes label math by goal (heart, triglycerides, brain, pregnancy). Trial-derived doses, not a prescription. The 70/30 trap: standard fish oil = 30% EPA+DHA. Concentrated fish oil = 60-90% EPA+DHA. The total fish-oil amount