Supplements

Rhodiola for Athletic Performance: What 14 Endurance RCTs Actually Show

If you're looking into rhodiola for athletic performance, the short answer is: it can help some endurance athletes in some conditions, but roughly two-thirds of the published RCTs found no significant performance effect, and the benefit when it appears is modest rather than transformative. This article breaks down the fourteen endurance trials that make up […]

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Rhodiola for Depression: An Honest Look at the Sertraline Comparison Trial and What It Actually Showed

If you're researching rhodiola for depression, you've probably heard that a 2015 clinical trial compared it directly to sertraline. Rhodiola showed real antidepressant activity in that trial, but it produced a meaningfully smaller effect than sertraline, with fewer side effects. This article breaks down exactly what the Mao 2015 study found, what the honest limitations

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Lion’s Mane Dosage: What Worked in RCTs vs What Marketing Claims

If you're searching for the right lion's mane dosage, the honest answer is: the clinical evidence is sparse and the two best human RCTs used doses that most products on store shelves either exceed or fall short of, without always saying why. This article breaks down exactly what those trials found, why fruiting body and

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Lion’s Mane for ADHD: What the Limited Cognitive RCT Data Suggests (and Doesn’t)

If you're searching for lion's mane for ADHD, the honest answer is: there is no published ADHD-specific randomized controlled trial for this mushroom, and any source claiming otherwise is misrepresenting the literature. What does exist is a small number of human RCTs on lion's mane for general cognitive function and mild cognitive impairment in older

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